Ava stin xeloda breast cancer











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Avastin is not licensed in the EU for the second-line treatment of patients with metastatic breast cancer. Avastin is approved in Europe for the treatment of advanced stages of breast cancer, colorectal cancer, non-small cell lung cancer, kidney cancer and ovarian cancer, and is available in the United States for the treatment of colorectal cancer, non-small cell lung cancer, kidney cancer and cervical cancer. About breast cancer Breast cancer is the most common cancer among women worldwide and approximately one in every eight women will be diagnosed with this disease. In addition, Avastin is approved in the United States and over 60 other countries worldwide for the treatment of patients with progressive glioblastoma following prior therapy. OS was a secondary endpoint of the study.

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Avastin Plus Commonly Used Chemotherapies Improved

TANIA is an open-label, randomised, multicentre phase III trial evaluating the efficacy and safety of Avastin-based therapy in the second-line setting in patients treated with Avastin plus chemotherapy as an initial first-line treatment for HER2-negative metastatic breast cancer. The primary endpoint was second-line progression-free-survival PFS , defined as the time from randomisation to second progression or death. secondary endpoints included overall survival OS from randomisation, overall response rate ORR and safety. Median PFS in the second-line was 6. The TANIA study met its primary endpoint of improving PFS, with a statistically significant 25 percent reduction in the risk of tumour progression for women who received Avastin plus chemotherapy in the second-line compared to chemotherapy alone median PFS. Further data, including OS, are expected in Avastin is approved in Japan for the treatment of the advanced stages of colorectal, non-small cell lung cancer, breast cancer, ovarian cancer and malignant glioma, including newly diagnosed glioblastoma.

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Avastin moderately active in advanced breast cancer

The stratified hazard ratio was 1. A second positive phase III study TANIA showed that women who received Avastin plus standard chemotherapy as initial treatment for their HER2-negative metastatic breast cancer and then continued with Avastin plus chemotherapy after their disease had progressed in the second-line setting , lived significantly longer without their disease getting worse, compared with people who received chemotherapy alone second-line. About Avastin — mechanism of action An independent blood supply is critical for a tumour to grow beyond a certain size 2mm and spread metastasise to other parts of the body. In addition, Avastin is approved in the United States and over 60 other countries worldwide for the treatment of patients with progressive glioblastoma following prior therapy. IMELDA is an open label, randomised, multicentre phase III study that investigated the efficacy and safety of maintenance treatment with Avastin plus Xeloda chemotherapy compared to Avastin alone, in patients whose HER2-negative metastatic breast cancer had not progressed during first-line induction treatment with Avastin plus docetaxel chemotherapy. It is recommended that Avastin treatment is continued until progression of the underlying disease or until unacceptable toxicity.

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Description: All trademarks used or mentioned in this release are protected by law. Arch Pathol Lab Med Avastin is an antibody that precisely targets and inhibits VEGF. Avastin has made anti-angiogenic therapy a fundamental pillar of cancer treatment today. In addition, Avastin is approved in the United States and over 60 other countries worldwide for the treatment of patients with progressive glioblastoma following prior therapy. Overall safety findings were consistent with those seen in previous trials of Avastin and Xeloda across tumour types for their approved indications, respectively. Results from patients showed..
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